MOTS-c Research Guide: The Mitochondrial-Derived Peptide

MOTS-c broke a biology rule: it is a 16-residue peptide encoded within the mitochondrial 12S rRNA gene — a region long assumed to encode nothing — making it the flagship of an entirely new class, the mitochondrial-derived peptides.

The mechanism

Published models associate MOTS-c with AMPK-pathway activation — the cell's master energy sensor and the same pathway engaged by exercise and caloric restriction. Under metabolic stress it translocates to the nucleus and modulates gene expression directly: a mitochondria-to-nucleus messenger.

The research wave

Exercise-mimetic framing put MOTS-c at the centre of metabolic and ageing research; age-related decline in circulating levels added the geroscience angle. It pairs naturally with NAD+ and SS-31 in mitochondria-focused programs — our longevity category groups all three.

Handling and sourcing

Standard lyophilised protocol. We stock 10mg vials, ≥99% HPLC-verified with batch COA, express Australia-wide.

If you run a peptide business, or are building one, we wholesale Australian-sourced stock to trade buyers across Australia.

All compounds discussed are for in-vitro laboratory research only and are not for human or veterinary use.